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Am J Physiol Cell Physiol 244: C303-C307, 1983;
0363-6143/83 $5.00
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AJP - Cell Physiology, Vol 244, Issue 3 303-C307, Copyright © 1983 by American Physiological Society

ARTICLES

Facilitated calcium diffusion by intestinal calcium-binding protein

J. J. Feher

The calcium flux through an aqueous compartment was determined using a flow-through dialysis cell in which two dialysis membranes isolated the aqueous compartment. Addition of the intestinal vitamin D-dependent calcium-binding protein (CaBP) significantly enhanced the calcium flux at near physiological calcium concentrations (1 X 10(-6) M). Bovine serum albumin had no effect on the calcium flux. CaBP appears to be one of a class of low molecular weight, soluble binding proteins that enhance ligand diffusion.


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