Am J Physiol Cell Physiol AJP: Lung Cellular and Molecular Physiology
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Am J Physiol Cell Physiol 241: C9-C17, 1981;
0363-6143/81 $5.00
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AJP - Cell Physiology, Vol 241, Issue 1 9-17, Copyright © 1981 by American Physiological Society

ARTICLES

Inward rectification in mouse macrophages: evidence for a negative resistance region

E. K. Gallin and D. R. Livengood

The electrical properties of cultured mouse thioglycollate-induced peritoneal macrophages were investigated using intracellular recording techniques. Thirty-five percent of the cells studied had membrane potentials ranging from -65 to -95 mV and exhibited S-shaped, steady-state current-voltage (I-V) relationships containing a transitional region. Analysis of currents in the transitional region from the rate of rise and fall of the voltage responses to current pulses indicated the presence of a negative resistance region in this area. Tetrodotoxin (3 X 10(-5) M), cobalt chloride (3 mM), 4-aminopyridine (4 mM), and tetraethylammonium chloride (8 mM) did not eliminate the transitional region of the I-V curves, whereas addition of barium chloride (4 mM) and rubidium chloride (3 mM) did. Increasing the external concentration of potassium shifted the I-V relationship horizontally along the current axis but did not eliminate the transitional region. These data indicate that the inward rectification and the negative resistance region probably result from a voltage-dependent potassium conductance.


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