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Am J Physiol Cell Physiol 237: C102-C110, 1979;
0363-6143/79 $5.00
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AJP - Cell Physiology, Vol 237, Issue 1 102-C110, Copyright © 1979 by American Physiological Society

ARTICLES

Lithium fluxes in human erythrocytes

B. E. Ehrlich and J. M. Diamond

The contribution of four transport pathways to Li+ influx and efflux in human erythrocytes was determined quantitatively, using Li+ concentrations comparable to those found in vivo when Li+ is used as treatment for manic-depressive illness. All pathways were measured simultaneously on each subject's blood sample to avoid possible temporal variations in transport parameters. We found that Li+ efflux is 75% via countertransport and 25% via a leak. The bicarbonate-sensitive pathway accounts for 30% of influx while the remaining 70% is via a leak. The Na+-K+ pump makes no significant contribution to Li+ influx or efflux under physiological conditions. Li+ efflux for a given [Li+]i is 3-5 times the Li+ influx for the same [Li+]o. However, due to interindividual variations in Na+-Li+ counter-transport, Li+ efflux but not influx varies considerably among individuals.


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Y. Chi, D. M. de Freitas, M. Sikora, and V. K. Bansal
Correlations of Na+-Li+ Exchange Activity With Na+ and Li+ Binding and Phospholipid Composition in Erythrocyte Membranes of White Hypertensive and Normotensive Individuals : A Nuclear Magnetic Resonance Investigation
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[Abstract] [Full Text]


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