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Am J Physiol Cell Physiol 233: C127-C134, 1977;
0363-6143/77 $5.00
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AJP - Cell Physiology, Vol 233, Issue 5 127-C134, Copyright © 1977 by American Physiological Society

ARTICLES

Regulation of tension in skinned muscle fibers: effect of high concentrations of Mg-ATP

M. Orentlicher, P. W. Brandt and J. P. Reuben

The control of tension in skinned fibers by Mg-ATP and Ca described in previous publications has been studied at high substrate concentrations over a wide range of temperature and salt concentration. Curves of tension versus pCa shift systemically to the right as [Mg-ATP] increases. The maximum Ca-activated tension of a skinned fiber declines at sufficiently high substrate concentrations. This behavior is described by a generalization of the scheme given in the earlier reports.


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